Question 1 · ERQ
22 marksEvaluate one or more biological explanations of one depressive disorder.
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Worked solution
### Essay Outline
#### 1. Introduction
- **Define the disorder**: Major Depressive Disorder (MDD) is a mood disorder characterized by persistent low mood, anhedonia, fatigue, and feelings of worthlessness.
- **Introduce biological explanations**:
- **Genetic arguments**: The idea that depression is inherited through genetic predisposition.
- **Neurochemical arguments**: The monoamine hypothesis, specifically focusing on the role of serotonin (5-HT).
- **Thesis Statement**: While biological explanations provide crucial insight and empirical support regarding the etiology of MDD, they must be understood within an interactionist framework (such as the diathesis-stress model) to avoid biological reductionism.
#### 2. Genetic Explanations of MDD
- **Theory**: Genetic inheritance models suggest that variations in specific genes increase susceptibility to MDD.
- **Key Study 1: Kendler et al. (2006)**
- **Aim**: To investigate the heritability of MDD in a large Swedish twin sample.
- **Method**: 42,161 twins assessed for lifetime MDD using DSM-IV criteria.
- **Findings**: Heritability of MDD was estimated to be around 38% overall, with higher rates in females (42%) than males (29%).
- **Conclusion**: MDD is moderately heritable, suggesting that genetics play a significant, but not exclusive, role in its development.
- **Key Study 2: Caspi et al. (2003)**
- **Aim**: To investigate whether a functional polymorphism in the 5-HTT gene moderates the influence of stressful life events on depression.
- **Method**: Longitudinal study of 847 New Zealanders. Participants were grouped based on their 5-HTT alleles (two short, one short/one long, or two long alleles).
- **Findings**: Participants with one or two short alleles who experienced multiple stressful life events exhibited more depressive symptoms and higher rates of diagnosed MDD compared to those with two long alleles.
- **Conclusion**: Genetic vulnerability (short 5-HTT alleles) interacts with environmental stress to increase the risk of depression (gene-environment interaction).
#### 3. Neurochemical Explanations (The Serotonin Hypothesis)
- **Theory**: Suggests that a deficit in the neurotransmitter serotonin in the synaptic cleft leads to the symptoms of depression.
- **Evidence**: Supported by the efficacy of Selective Serotonin Reuptake Inhibitors (SSRIs) like fluoxetine (Prozac), which increase serotonin availability in the synapse and alleviate depressive symptoms for many patients.
#### 4. Critical Evaluation of Biological Explanations
- **Strengths**:
- Strong empirical support from large-scale twin studies and molecular genetics.
- Practical application: Led to highly effective pharmacological treatments (SSRIs), reducing the stigma of depression by reframing it as a physiological illness.
- **Limitations**:
- **Treatment-Etiology Fallacy**: Assuming that because SSRIs alleviate symptoms by raising serotonin, a lack of serotonin must have caused the disorder. This is like assuming a headache is caused by a lack of aspirin.
- **Reductionism**: Biological explanations often ignore cognitive factors (e.g., Beck's cognitive triad) and sociocultural factors (e.g., poverty, chronic stress, isolation).
- **Bidirectional Ambiguity**: It is difficult to determine whether chemical imbalances cause depressive thoughts, or whether prolonged negative thinking patterns alter brain chemistry.
- **Incompleteness**: Low heritability rates (around 38%) mean that more than half of the variance in MDD is accounted for by environmental factors.
#### 5. Conclusion
- Conclude that biological explanations are essential for identifying vulnerabilities and developing medical treatments, but they are insufficient on their own. A holistic approach (biopsychosocial model) that integrates genetic predisposition with cognitive vulnerability and environmental stressors is required for a complete understanding of depression.
#### 1. Introduction
- **Define the disorder**: Major Depressive Disorder (MDD) is a mood disorder characterized by persistent low mood, anhedonia, fatigue, and feelings of worthlessness.
- **Introduce biological explanations**:
- **Genetic arguments**: The idea that depression is inherited through genetic predisposition.
- **Neurochemical arguments**: The monoamine hypothesis, specifically focusing on the role of serotonin (5-HT).
- **Thesis Statement**: While biological explanations provide crucial insight and empirical support regarding the etiology of MDD, they must be understood within an interactionist framework (such as the diathesis-stress model) to avoid biological reductionism.
#### 2. Genetic Explanations of MDD
- **Theory**: Genetic inheritance models suggest that variations in specific genes increase susceptibility to MDD.
- **Key Study 1: Kendler et al. (2006)**
- **Aim**: To investigate the heritability of MDD in a large Swedish twin sample.
- **Method**: 42,161 twins assessed for lifetime MDD using DSM-IV criteria.
- **Findings**: Heritability of MDD was estimated to be around 38% overall, with higher rates in females (42%) than males (29%).
- **Conclusion**: MDD is moderately heritable, suggesting that genetics play a significant, but not exclusive, role in its development.
- **Key Study 2: Caspi et al. (2003)**
- **Aim**: To investigate whether a functional polymorphism in the 5-HTT gene moderates the influence of stressful life events on depression.
- **Method**: Longitudinal study of 847 New Zealanders. Participants were grouped based on their 5-HTT alleles (two short, one short/one long, or two long alleles).
- **Findings**: Participants with one or two short alleles who experienced multiple stressful life events exhibited more depressive symptoms and higher rates of diagnosed MDD compared to those with two long alleles.
- **Conclusion**: Genetic vulnerability (short 5-HTT alleles) interacts with environmental stress to increase the risk of depression (gene-environment interaction).
#### 3. Neurochemical Explanations (The Serotonin Hypothesis)
- **Theory**: Suggests that a deficit in the neurotransmitter serotonin in the synaptic cleft leads to the symptoms of depression.
- **Evidence**: Supported by the efficacy of Selective Serotonin Reuptake Inhibitors (SSRIs) like fluoxetine (Prozac), which increase serotonin availability in the synapse and alleviate depressive symptoms for many patients.
#### 4. Critical Evaluation of Biological Explanations
- **Strengths**:
- Strong empirical support from large-scale twin studies and molecular genetics.
- Practical application: Led to highly effective pharmacological treatments (SSRIs), reducing the stigma of depression by reframing it as a physiological illness.
- **Limitations**:
- **Treatment-Etiology Fallacy**: Assuming that because SSRIs alleviate symptoms by raising serotonin, a lack of serotonin must have caused the disorder. This is like assuming a headache is caused by a lack of aspirin.
- **Reductionism**: Biological explanations often ignore cognitive factors (e.g., Beck's cognitive triad) and sociocultural factors (e.g., poverty, chronic stress, isolation).
- **Bidirectional Ambiguity**: It is difficult to determine whether chemical imbalances cause depressive thoughts, or whether prolonged negative thinking patterns alter brain chemistry.
- **Incompleteness**: Low heritability rates (around 38%) mean that more than half of the variance in MDD is accounted for by environmental factors.
#### 5. Conclusion
- Conclude that biological explanations are essential for identifying vulnerabilities and developing medical treatments, but they are insufficient on their own. A holistic approach (biopsychosocial model) that integrates genetic predisposition with cognitive vulnerability and environmental stressors is required for a complete understanding of depression.
Marking scheme
### IB Psychology ERQ Rubric (22 Marks)
#### Criterion A: Focus on the question (2 marks)
- **2 marks**: The response is fully focused on the question, clearly evaluating one or more biological explanations (genetic/neurochemical) of MDD throughout.
- **1 mark**: The response identifies biological explanations but lacks consistent focus on evaluating them, or discusses a non-depressive disorder.
#### Criterion B: Knowledge and understanding (6 marks)
- **5-6 marks**: Detailed and accurate knowledge of biological explanations (e.g., 5-HTT gene, serotonin hypothesis) and relevant concepts (e.g., heritability, diathesis-stress model) is demonstrated.
- **3-4 marks**: Good knowledge is demonstrated, but there may be some minor inaccuracies or omissions in describing the biological mechanisms.
- **1-2 marks**: Limited or superficial knowledge of biological explanations.
- **0 marks**: No relevant knowledge demonstrated.
#### Criterion C: Use of research (6 marks)
- **5-6 marks**: Relevant research (such as Kendler et al. or Caspi et al.) is used effectively and accurately to support the explanation. The studies are described and explicitly linked to the essay's arguments.
- **3-4 marks**: Relevant research is cited, but description is incomplete or the link to the explanation is weak.
- **1-2 marks**: Research is mentioned but is highly inaccurate, irrelevant, or lacks detail.
#### Criterion D: Critical thinking (6 marks)
- **5-6 marks**: Reflects a well-developed evaluation of the biological explanations. Evaluative points (e.g., reductionism, treatment-etiology fallacy, bidirectional ambiguity, gene-environment interactions) are well-developed and balanced.
- **3-4 marks**: Some evaluation is present (e.g., strengths and limitations), but it tends to be descriptive or relies on pre-packaged evaluation points without deep synthesis.
- **1-2 marks**: Evaluation is superficial, generic (e.g., "this study has low ecological validity" without explanation), or missing.
#### Criterion E: Clarity and organization (2 marks)
- **2 marks**: The essay is well-structured, logical, and uses appropriate psychological terminology throughout.
- **1 mark**: The essay has some structure but lacks flow, or psychological terminology is used inappropriately.
#### Criterion A: Focus on the question (2 marks)
- **2 marks**: The response is fully focused on the question, clearly evaluating one or more biological explanations (genetic/neurochemical) of MDD throughout.
- **1 mark**: The response identifies biological explanations but lacks consistent focus on evaluating them, or discusses a non-depressive disorder.
#### Criterion B: Knowledge and understanding (6 marks)
- **5-6 marks**: Detailed and accurate knowledge of biological explanations (e.g., 5-HTT gene, serotonin hypothesis) and relevant concepts (e.g., heritability, diathesis-stress model) is demonstrated.
- **3-4 marks**: Good knowledge is demonstrated, but there may be some minor inaccuracies or omissions in describing the biological mechanisms.
- **1-2 marks**: Limited or superficial knowledge of biological explanations.
- **0 marks**: No relevant knowledge demonstrated.
#### Criterion C: Use of research (6 marks)
- **5-6 marks**: Relevant research (such as Kendler et al. or Caspi et al.) is used effectively and accurately to support the explanation. The studies are described and explicitly linked to the essay's arguments.
- **3-4 marks**: Relevant research is cited, but description is incomplete or the link to the explanation is weak.
- **1-2 marks**: Research is mentioned but is highly inaccurate, irrelevant, or lacks detail.
#### Criterion D: Critical thinking (6 marks)
- **5-6 marks**: Reflects a well-developed evaluation of the biological explanations. Evaluative points (e.g., reductionism, treatment-etiology fallacy, bidirectional ambiguity, gene-environment interactions) are well-developed and balanced.
- **3-4 marks**: Some evaluation is present (e.g., strengths and limitations), but it tends to be descriptive or relies on pre-packaged evaluation points without deep synthesis.
- **1-2 marks**: Evaluation is superficial, generic (e.g., "this study has low ecological validity" without explanation), or missing.
#### Criterion E: Clarity and organization (2 marks)
- **2 marks**: The essay is well-structured, logical, and uses appropriate psychological terminology throughout.
- **1 mark**: The essay has some structure but lacks flow, or psychological terminology is used inappropriately.