題目 1 · SAQ
9 分Explain the role of one gene in one human behaviour, with reference to one study.
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解題
One gene that has been shown to play a role in human behaviour is the 5-HTT gene, which is associated with the development of major depressive disorder (depression) in response to environmental stressors. The 5-HTT gene codes for the serotonin transporter protein, which regulates the reuptake of serotonin in the synaptic cleft. The gene has two primary alleles: the long allele (associated with more efficient serotonin reuptake) and the short allele (associated with less efficient serotonin reuptake and reduced resilience to stress).
A key study investigating this relationship is Caspi et al. (2003). The researchers aimed to determine whether there is an interaction between the 5-HTT gene and life stress in predicting depression. The study utilized a longitudinal design with a sample of 847 New Zealand participants, who were divided into three groups based on their 5-HTT alleles: Group 1 had two short alleles (s/s), Group 2 had one short and one long allele (s/l), and Group 3 had two long alleles (l/l). The participants' life events between the ages of 21 and 26 were assessed using a life-history calendar, and depression symptoms were evaluated at age 26.
The results showed that participants with one or more short alleles (s/s or s/l) who experienced multiple stressful life events demonstrated a significant increase in depressive symptoms, diagnosed depression, and suicidal ideation compared to participants with two long alleles (l/l) who experienced similar levels of stress. Participants with two long alleles showed no significant increase in depression, even when exposed to multiple stressful life events.
This study demonstrates that the 5-HTT gene does not directly cause depression, but rather moderates an individual's vulnerability to environmental stressors. Individuals carrying the short allele are genetically predisposed to be more sensitive to stress, illustrating the gene-environment interaction (diathesis-stress model) in shaping human behaviour.
A key study investigating this relationship is Caspi et al. (2003). The researchers aimed to determine whether there is an interaction between the 5-HTT gene and life stress in predicting depression. The study utilized a longitudinal design with a sample of 847 New Zealand participants, who were divided into three groups based on their 5-HTT alleles: Group 1 had two short alleles (s/s), Group 2 had one short and one long allele (s/l), and Group 3 had two long alleles (l/l). The participants' life events between the ages of 21 and 26 were assessed using a life-history calendar, and depression symptoms were evaluated at age 26.
The results showed that participants with one or more short alleles (s/s or s/l) who experienced multiple stressful life events demonstrated a significant increase in depressive symptoms, diagnosed depression, and suicidal ideation compared to participants with two long alleles (l/l) who experienced similar levels of stress. Participants with two long alleles showed no significant increase in depression, even when exposed to multiple stressful life events.
This study demonstrates that the 5-HTT gene does not directly cause depression, but rather moderates an individual's vulnerability to environmental stressors. Individuals carrying the short allele are genetically predisposed to be more sensitive to stress, illustrating the gene-environment interaction (diathesis-stress model) in shaping human behaviour.
評分準則
Marks are awarded based on the standard IB Psychology SAQ rubric (9 marks total):
- **1 to 3 marks**: The response demonstrates limited understanding of the role of a gene on behaviour. The gene or behaviour may not be clearly identified, or the study description is highly inaccurate or missing.
- **4 to 6 marks**: The response identifies a gene (5-HTT) and a behaviour (depression) but the explanation of the link is basic or lacks detail. A relevant study (Caspi et al., 2003) is described, but its integration with the explanation is weak or incomplete.
- **7 to 9 marks**: The response is well-focused and demonstrates highly accurate knowledge. The biological mechanism of the gene (5-HTT's role in serotonin reuptake) is clearly explained in relation to the behaviour (depression). The study by Caspi et al. (2003) is described accurately (aim, method, findings) and is explicitly and effectively linked to show how the gene influences behaviour.
- **1 to 3 marks**: The response demonstrates limited understanding of the role of a gene on behaviour. The gene or behaviour may not be clearly identified, or the study description is highly inaccurate or missing.
- **4 to 6 marks**: The response identifies a gene (5-HTT) and a behaviour (depression) but the explanation of the link is basic or lacks detail. A relevant study (Caspi et al., 2003) is described, but its integration with the explanation is weak or incomplete.
- **7 to 9 marks**: The response is well-focused and demonstrates highly accurate knowledge. The biological mechanism of the gene (5-HTT's role in serotonin reuptake) is clearly explained in relation to the behaviour (depression). The study by Caspi et al. (2003) is described accurately (aim, method, findings) and is explicitly and effectively linked to show how the gene influences behaviour.