Table 1.1 shows information about three of these structures.
Complete Table 1.1 by filling in the missing names of structures, functions, or the representative letters based on your knowledge of the alimentary canal.
**Table 1.1**
| Name of the structure | Function | Representative letter on a diagram |
| :--- | :--- | :---: |
| Stomach | ........................................................................ | **S** |
| ......................................... | produces pancreatic juice containing amylase, trypsin, and lipase | **P** |
| Gallbladder | stores ................................................................ | **G** |
| ......................................... | produces bile | **L** |
[4]
(b) (i) Describe the role of physical digestion in the alimentary canal. [3]
(ii) State the soluble product of complete protein digestion. [1]
(iii) Name the specific region of the alimentary canal where these digested products are absorbed into the blood. [1]
(iv) Explain why pepsin actively breaks down protein molecules in the stomach but cannot break them down in the duodenum. [6]
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解题
* **Stomach Function**: Churns food (mechanical digestion) OR secretes gastric juice / hydrochloric acid / pepsin.
* **Structure P**: Pancreas (produces pancreatic amylase, trypsin, and lipase).
* **Gallbladder Function**: Stores bile (which emulsifies fats).
* **Structure L**: Liver (produces bile).
**1 (b) (i)**
Physical digestion is the breakdown of food into smaller pieces without chemical alteration of the food molecules. It:
1. Increases the surface area of food for chemical digestion by enzymes.
2. Mixes food with digestive juices.
3. Makes food easier to swallow and pass through the alimentary canal via peristalsis.
**1 (b) (ii)**
Amino acids.
**1 (b) (iii)**
Ileum (accept small intestine / villi).
**1 (b) (iv)**
1. The stomach contains hydrochloric acid, creating an acidic environment (low pH) which is the optimum pH for pepsin activity.
2. In the duodenum (small intestine), bile and pancreatic juice (containing sodium hydrogencarbonate) are secreted.
3. These secretions are alkaline, neutralising the stomach acid and raising the pH to neutral or slightly alkaline.
4. This change in pH denatures the pepsin enzyme.
5. Denaturation alters the shape of pepsin's active site.
6. The active site is no longer complementary in shape to the protein substrate, meaning enzyme-substrate complexes cannot form.
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Four correct inputs to complete the table (one mark per correct row) [4]:
* **Row 1**: churns food / mixes food / secretes gastric juice / secretes hydrochloric acid / secretes pepsin
* **Row 2**: pancreas
* **Row 3**: bile
* **Row 4**: liver
**1 (b) (i)**
Any three from [3]:
* breaks down food into smaller pieces / breaks down food without chemical change / physical reduction in size;
* increases surface area (for enzyme action / chemical digestion);
* makes food easier to swallow / lubricates food;
* increases ease of passage / movement through the alimentary canal / aids peristalsis;
* mixes food with digestive enzymes / bile;
**1 (b) (ii)**
* amino acids [1]
**1 (b) (iii)**
* ileum / small intestine / villi [1]
*(Reject: large intestine, duodenum, stomach)*
**1 (b) (iv)**
Any six from [6]:
* stomach has gastric juice / hydrochloric acid / low pH / acidic pH;
* (stomach pH) is the optimum pH for pepsin;
* bile / pancreatic juice / pancreatic secretions are released into the duodenum / small intestine;
* these secretions are alkaline / contain sodium hydrogencarbonate;
* neutralise (stomach / gastric) acid / raise pH;
* (higher / alkaline pH in duodenum) denatures pepsin;
* alters the shape of the active site (of pepsin);
* active site is no longer complementary to the substrate / protein molecule;
* enzyme-substrate complexes can no longer form / cannot form / pepsin becomes inactive;
*(Accept: reverse argument (ora) for pancreatic proteases / trypsin where appropriate)*